One of the main branches of entrepreneurship is entrepreneurial orientation as it certainly plays an important role in the success and growth of the organizations. Entrepreneurial orientation is rooted in adopting a strategy. Many organizational policies which are formulated for the development of entrepreneurship are associated with information and communication technologies, in the other hand, from the perspective of social scientists; entrepreneurship is a process that locates the network of social relations. The aim of this study is to analyze the impact of information technology and social capital on entrepreneurial orientation. The study is applied and its method is Descriptive-correlation. The study population consisted of 326 employees at ALBORZ drug corporate. A study sample of 177 subjects was selected through application of Cochran formula at random. The three questionnaires (information technology, social capital and entrepreneurial orientation) Was used for data collection. The Validity (content, convergent, divergent) and Reliability (Loadings factors, composite reliability coefficient, Cronbach's alpha coefficient) of questionnaires showed that measurement tools have very good reliability and validity. Test results of the variable by applying SMART-PLS software and using of T- test statistic and the path coefficients (β) showed that Information Technology has a strong direct and significant effect on social capital; while social capital has a direct and significant weak effect on entrepreneurial orientation. Moreover, Information technology has a strong direct, indirect and significant effect on entrepreneurial orientation. This means that while social capital has the mediator role in relationship between information technology and entrepreneurial orientation information technology as a moderator variable increases the positive impact of social capital on entrepreneurial orientation.