The research is set to examine Academic Staff Union of Universities (ASUU) strikes and academic performance of students in Ekiti State University (EKSU) Ado-Ekiti. The research employed multistage sampling technique to select the faculties and the departments from where six hundred and four (604) respondents were selected, questionnaires and interviews were employed to draw information from respondents. The findings showed that the incessant strikes action by ASUU in Nigeria have disrupted the academic calendar of Universities and this has affected students’ academic pursuit and performance, 71.2% of the respondents have experienced ASUU strikes and 51.6% admitted that ASUU strikes have had negative influence on their academics. Almost sixty percent [59.5%] believed that government can find a lasting solution to the problems of ASUU strikes through prompt and rewarding dialogue that grants the request of ASUU timely. The study suggests and recommends that university students should engage themselves in tutorial classes or self-study during the strike action to keep them abreast with academics at resumption, their parents or guardians should ensure that they encourage students engagement in academic activities rather than domestic chores while the strike last, the members and the executives of ASUU should employ other industrial dispute strategies to express their grievances rather than embark on indefinite strike action which obviously paralyses student’s academics. The Nigerian Government should also employ the method of prompt dialogue and grant the requests of ASUU in time to prevent erosion and total breakdown of the educational sector.