The present study aims at recognizing and analyzing the relationship among variables such as stress, social capital, self esteem and the locus of control that affect the high school students’ quality of life in Fars province, Iran. To this end 224 high school students form Shiraz, Kazerun, and Marvdasht were selected as participants based on Cluster Sampling. Cronbach’s alpha was used to measure the reliability of the questionnaire used, while its validity was determined through Item Analysis and expert consensus. The research findings indicated that there was a significant and positive correlation among such variables as self-esteem, locus of control, social capital and the students’ quality of life, while variables such as the quality of life and stress revealed a negative correlation. All coefficients at p< .05 level were significant. The Beta for locus of control, self – esteem, social capital, and stress were 0.28, 0.23, 0.21, - 0.18 respectively. Locus of control plays a crucial role in the students’ quality of life. This is to say that internal locus of control means a better quality of life and living standards. All coefficients were significant at p< 0.05.